Synthesis, Radiochemistry, and Preclinical Assessment of the First GPR39 PET Imaging Agent

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DOI:10.1021/acs.jmedchem.5c03351
作者：Bhuvanachandra Bhoopal,?, ,?Krishna Kumar Gollapelli,?, ,?Naresh Damuka,?, ,?Ivan Krizan,?, ,?Mack Miller,?, ,?Ryan W. Fitzgerald,?, ,?Nishka Amesar,?, ,?Dundappa Mumbaraddi,?, ,?Dongqin Zhu,?, ,?Rita
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American Chemical Society (ACS)

Abstract：GPR39 is a zinc-sensing G protein-coupled receptor with critical roles in neurophysiological and metabolic processes across brain, pancreas, gut, liver, and fat tissues. Activated by extrace

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