REM-422, a Potent, Selective, Oral Small Molecule mRNA Degrader of the MYB Oncogene, Demonstrates Anti-Tumor Activity in Mouse Xenograft Models of AML

已完结 20 由达姆发布于 2025/11/13 15:41:00

DOI:10.1182/blood-2023-182676
作者：Sudeep Prajapati, Michael Cameron, Bryan M. Dunyak, Mengge Shan, Y. A. Siu, Samantha Levin-Furtney, Joshua Powe, Eileen T.M. Burchfiel, Sarah E. Cabral, Alycen M. Harney, Regina K. Keenan, Kevin Larpe
文献类型：期刊论文
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American Society of Hematology (ASH)

Abstract：The c-MYB (MYB) oncogenic transcription factor is a key regulator of hematopoietic cell differentiation and proliferation. Recurrent genetic lesions or dysregulation of MYB have been identif

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