Tumor-Associated Macrophages Produce PGE2 to Promote CD8+ T Cell Exhaustion and Drive Resistance to PD-L1 Blockade in Microsatellite Stable Colorectal Cancer

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DOI:10.1158/0008-5472.can-25-0079
作者：Jean-David Fumet, Charlène Latour, Lisa Nuttin, Valentin Derangère, Alis Ilie, Pauline Russo, Léa Hampe, Susy Daumoine, Marion Thibaudin, Caroline Truntzer, Francois Ghiringhelli, Emeric Limagne
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American Association for Cancer Research (AACR)

Abstract：Immune checkpoint blockade treatment is highly effective in microsatellite instable (MSI) colorectal cancer (CRC). However, microsatellite stable (MSS) tumors, are intrinsically resistant to

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