Development of a Scalable Synthesis for the Spirocyclic Benzoxepane–Pyridine Core of FXR Agonist HEC96719

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DOI:10.1021/acs.oprd.6c00078
作者：Jiayang Zhang,?Junwen Wu,?Shengqiang Pan,?Hong Chen,?Zhongqing Wang,?Xiaoyun Lu,?Xinye Yang* and Yingjun Zhang*,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：HEC96719 is a small-molecule farnesoid X receptor (FXR) agonist with potential for treating nonalcoholic steatohepatitis (NASH). Herein, we report a robust and scalable kilogram-scale synthe

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