High affinity and low PARP-trapping benzimidazole derivatives as a potential warhead for PARP1 degraders

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DOI:10.1016/j.ejmech.2024.116405
文献类型：期刊论文
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Elsevier

Abstract：PARPi have been explored and applied in the treatment of various cancers with remarkable efficacy, especially BRCA1/2 mutated ovarian, breast, prostate, and pancreatic cancers. However, PARP

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