CYP3A Mediates an Unusual C(sp2)?C(sp3) Bond Cleavage via Ipso-Addition of Oxygen in Drug Metabolism

已完结 20 由 pp 发布于 2025/7/24 9:26:14

DOI:10.1002/ange.202405197
作者：Dr. Xuan Qin,?Dr. Yong Wang,?Dr. Qiuji Ye,?John M. Hakenjos,?Prof.?Dr. Jin Wang,?Prof.?Dr. Mingxing Teng,?Prof.?Dr. Lei Guo,?Prof.?Dr. Zhi Tan,?Prof.?Dr. Damian W. Young,?Prof.?Dr. Kevin R. MacKenzie,
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Wiley

Abstract：Mammalian cytochrome P450 drug-metabolizing enzymes rarely cleave carbon–carbon (C−C) bonds and the mechanisms of such cleavages are largely unknown. We identified two unusual cleavages of n

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