Admixing of mRNA with Pre-Formed Lipid Nanoparticles Containing a Slightly-Cationic Ionizable Lipid Allows for Efficient mRNA Transfection In Vitro and In Vivo.

已完结 20 由酒酿丸子发布于 2025/7/23 17:48:44

DOI:10.1002/adhm.202501788
作者：Haixiu Wang,?Heleen Lauwers,?Mark Gontsarik,?Yong Chen,?Niek N Sanders,?Miffy Hok Yan Cheng,?Bruno G De Geest,?Zifu Zhong
文献类型：期刊论文
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Wiley

Abstract：Therapeutic mRNA has emerged as a powerful tool in medicine. However, due to its fragility and large size, mRNA requires a carrier for delivery into the cellular cytosol. Lipid nanoparticles

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