The safety of recombinant human hyaluronidase PH20 in nonclinical models: An overview of toxicology, pharmacology, and impact of anti-PH20 antibodies

已完结 20 由周美玲发布于 2025/7/29 14:05:55

DOI:10.1016/j.jconrel.2024.07.062
作者：Ryan P. Nolan ,?David W. Kang ,?Daniel C. Maneval ,?Stephen P. Knowles ,?Michael J. LaBarre ,?Marie A. Printz
文献类型：期刊论文
补充材料：只需要正文

Elsevier

Abstract：Hyaluronan (HA) is a glycosaminoglycan that forms a gel-like barrier in the subcutaneous (SC) space, limiting bulk fluid flow and the dispersion of SC-administered therapeutics. Recombinant

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