Co-delivery of protopanaxatriol/icariin into niche cells restores bone marrow niches to rejuvenate HSCs for chemotherapy-induced myelosuppression

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DOI:10.1016/j.phymed.2024.155978
作者：Mengdi Xiao ,?Shiyi Hong ,?Pei Peng ,?Siying Cai ,?Yutian Huang ,?Jing Liang ,?Xue Bai ,?Qiying Bao ,?Wei Li ,?Guilin Cheng ,?Yang Xiong ,?Mancang Gu ,?Chaofeng Mu
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Abstract：BackgroundUp to 80 % of chemotherapeutic drugs induce myelosuppression in patients. Chemotherapy not only impairs of hematopoietic stem cells (HSCs) but also damages bone marrow niches (vasc

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