Somatic hypermutation unlocks antibody specificities beyond the primary repertoire

已完结 10 由 000 发布于 2025/8/1 16:32:05

DOI:10.1016/j.immuni.2025.04.014
作者：Teng Zuo, Avneesh Gautam, Shahab Saghaei, Sweta N. Khobragade, Rahaman Ahmed, Azadeh Mahdavinia, Mehrdad Zarghami, Gaspar A. Pacheco, Kenneth Green, Meghan Travers, Nicholas Garcia, Zahra Allahyari, V
文献类型：期刊论文
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文献链接：https://doi.org/10.1016/j.immuni.2025.04.014

Elsevier

Abstract：B cell somatic hypermutation (SHM) and selection in germinal centers (GCs) enhance antibody affinity for antigen. Here, we investigated whether SHM-based antibody evolution is restricted to

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