Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation

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DOI:10.1016/j.cmet.2025.03.011
作者：Eric Ravussin, Guillermo Sanchez-Delgado, Corby K. Martin, Robbie A. Beyl, Frank L. Greenway, Libbey S. O’Farrell, William C. Roell, Hui-Rong Qian, Jing Li, Hiroshi Nishiyama, Axel Haupt, Edward J. P
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Abstract：Tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, promoted significant body weight reduction in the phase 3 clinical trials. We conduc

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