Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver

已完结 20 由嘉发布于 2025/8/11 15:52:20

DOI:10.1038/s41551-022-00847-9
作者：Cory D. Sago, Melissa P. Lokugamage, David Loughrey, Kevin E. Lindsay, Robert Hincapie, Brandon R. Krupczak, Sujay Kalathoor, Manaka Sato, Elisa Schrader Echeve
文献类型：期刊论文
补充材料：只需要正文

Nature

Abstract：Systemically delivered lipid nanoparticles are preferentially taken up by hepatocytes. This hinders the development of effective, non-viral means of editing genes in tissues other than the l

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