De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy

已完结 20 由 5 发布于 2025/8/14 8:32:21

DOI:10.1002/anie.202504233
作者：Huiling Zhou,&nbsp;Bo Hou,&nbsp;Yiming Shan,&nbsp;Lujia Huang,&nbsp;Fangmin Chen,&nbsp;Siyuan Ren,&nbsp;Shunan Zhang,&nbsp;Jiaxing Pan,&nbsp;Yijing Dang,&nbsp;Haiju
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Abstract：Targeted protein degradation (TPD) technology holds significant potential for modulating protein homeostasis and treating diseases. However, current methods for degrading membrane proteins h

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