Enhancing siRNA efficacy in vivo with extended nucleic acid backbones.

已完结 10 由安东尼发布于 2025/6/27 18:17:47

DOI:10.1038/s41587-024-02336-7
作者：Ken Yamada, Vignesh N Hariharan, Jillian Caiazzi, Rachael Miller, Chantal M Ferguson, Ellen Sapp, Hassan H Fakih, Qi Tang, Nozomi Yamada, Raymond C Furgal,
文献类型：期刊论文
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Nature

Abstract：Therapeutic small interfering RNA (siRNA) requires sugar and backbone modifications to inhibit nuclease degradation. However, metabolic stabilization by phosphorothioate (PS), the only backb

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