Mechanism-Based Multitarget Modeling for Pathway-Level Prediction of PI3K/Akt Signaling Perturbation Induced by Liquid Crystal Monomers

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DOI:10.1021/acs.est.6c00371
作者：Jiawei Cheng,?Yuhe He,?Yawen Yuan,?Yunsong Mu*,?Xiaoli Zhao,?Fengchang Wu,?Christie M. Sayes and John P. Giesy,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Liquid crystal monomers (LCMs) are emerging contaminants whose system-level toxicity mechanisms remain poorly understood. Here, we developed a pathway-centric multitarget framework to charac

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