Targeting cancer-specific mutations with RNA-triggered chromatin shredding.

已完结 10 由 Ann 发布于 2026/7/30 19:50:27

DOI:10.1038/s41586-026-10738-7
作者：Jingkun Zeng,?Zhiyuan Cheng,?Huadong Chen,?Zhaojun Wang,?Jared Thompson,?Kadin T Crosby,?Hesong Han,?Arushi Singhal,?Wayne Ngo,?Chenglong Xia,?Daniel Rosas-Rivera,?Zeyuan Zhang,?Min Hyung Kang,?Ying M
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Nature

Abstract：Genetic mutations that drive cancer often occur in tumour-suppressor proteins such as the p53 transcription factor, which is altered in 40-50% of cases1,2. However, current therapies often f

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