Preferential tumor targeting of HER2 by iPSC-derived CAR T cells engineered to overcome multiple barriers to solid tumor efficacy

已完结 10 由 1 发布于 2025/7/5 17:16:48

DOI:10.1016/j.stem.2025.05.007
作者：Martin P. Hosking, Soheila Shirinbak, Kyla Omilusik, Shilpi Chandra, Mika K. Kaneko, Angela Gentile, Susumu Yamamoto, Bishwas Shrestha, Joy Grant, Megan Boyett, Demetrio Cardenas, Hannah Keegan, Samad
文献类型：期刊论文
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Elsevier

Abstract：Chimeric antigen receptor (CAR) T cell therapies in solid tumors have been limited by on-target, off-tumor toxicity, antigen heterogeneity, and an inability to simultaneously overcome multip

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