Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics

已完结 10 由 Plexera 发布于 2025/7/4 12:30:55

DOI:10.1016/j.chembiol.2024.11.005
作者：J. Sebastian Temme ,?Zibin Tan ,?Mi Li ,?Mo Yang ,?Alexander Wlodawer ,?Xuefei Huang ,?John S. Schneekloth Jr. ,?Jeffrey C. Gildersleeve
文献类型：期刊论文
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Elsevier

Abstract：Polysaccharide intercellular adhesin (PIA), an exopolysaccharide composed of poly-N-acetyl glucosamine (PNAG), is an essential component in many pathogenic biofilms. Partial deacetylation of

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