Process Development and GMP Production of a Conjugate Warhead: Auristatin F-HPA-Ala/TFA (XMT-1864/TFA)

已完结 10 由 lindlarcat 发布于 2025/7/7 22:09:57

DOI:10.1021/acs.oprd.1c00449
作者：Patrick R. Conlon,?Venu Reddy Gurijala,?Michael Kaufman,?Dachang Li,?Jiuyuan Li*,?Yuanyuan Li,?Mao Yin,?Bollu Satyanarayan Reddy,?Thomas Wagler,?Zedong Wang,?Zhongmin Xu,?Aleksandr V. Yurkovetskiy and
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：An efficient, large-scale manufacturing process is described for XMT-1864/TFA (1-TFA), an auristatin F derivative, used as a novel, highly potent, cytotoxic warhead in Mersana’s oncology ant

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