Interaction of the antiarrhythmic drug Amiodarone with the sodium channel Nav1.5 depends on the extracellular pH

已完结 10 由眼镜胖子发布于 2025/7/6 21:44:27

DOI:10.1016/j.ejphar.2023.176127
作者：Michael Ramon de Lima Concei??o ,?Jorge Lucas Teixeira-Fonseca ,?Leisiane Pereira Marques ,?Diego Santos Souza ,?Danilo Roman-Campos
文献类型：期刊论文
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Elsevier

Abstract：IntroductionAmiodarone (AMD) is a clinically used drug to treat arrhythmias with significant effect upon the cardiac sodium channel Nav1.5. AMD has a pKa of 6.56, and changes in extracellula

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