Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in Glucuronidation.

已完结 20 由 YAN 发布于 2025/7/9 16:15:00

DOI:10.1124/dmd.123.001289
作者：Shuai Wang,?Shuguang Ma,?Eugene Chen,?Jing Wang,?Hoa Le,?Steven Paul Hanlon,?Martin Binder,?Wendy Lee,?S Cyrus Khojasteh,?Laurent Salphati
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Abstract：Navoximod (GDC-0919) is a small molecule inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) developed to reduce T cell immunosuppression associated with cancer. This study describes the absor

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