A Novel Attenuated CD122-Biased IL15 Mutein Promotes Strong NK and T Cell-Dependent Antitumor Immunity.

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DOI:10.1158/1535-7163.MCT-25-0625
作者：Mengmeng Sun, Shuang Wang, Yue Wu, Ruipu Xin, Shangting Zhang, Bo Huang, Yan Chen, Yu Liang, Tengfei Yu, Jianqing Xu, Jijie Gu, Lei Wu
文献类型：期刊论文
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American Association for Cancer Research (AACR)

Abstract：Interleukin-15 (IL15) potentiates NK and T cell immunity and has huge potential for tumor immunotherapy. However, the clinical prospects of IL15 has been hindered by poor pharmacokinetics an

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