Process development and optimization of apalutamide synthesis aided by the Design of Experiments (DoE)

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DOI:10.1016/j.tet.2025.134725
作者：Hailong Wang ,?Lijun Li ,?Fubin Yang ,?Dongming Li ,?Shuming Wu ,?Wei Yan ,?Guodong Sun ,?Jie Tan ,?Yishao Li ,?Hua Yang ,?Zhongqing Wang
文献类型：期刊论文
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Elsevier

Abstract：In this manuscript, the process of apalutamide synthesis was efficiently optimized with the guidance of Design of Experiments (DoE). By employing Definitive Screening Designs and Custom Desi

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