Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats

已完结 20 由 YAN 发布于 2025/7/17 14:13:54

DOI:10.1080/00498254.2022.2062685
作者：Chenghong Zhang,?Sung-Ji Cho,?J. Napolitano,?David J Russell,?Christine Gu,?A. Deese,?C. Han,?Yuan Chen,?Shuguang Ma
文献类型：期刊论文
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Abstract：Abstract 1. GDC-0575 is an ATP-competitive small-molecule inhibitor of ChK1 that is being developed by Genentech for the treatment of various human malignancies. 2. In a radiolabeled mass ba

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