Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

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DOI:10.1021/acs.jmedchem.0c02023
文献类型：期刊论文
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文献链接：https://doi.org/10.1021/acs.jmedchem.0c02023

American Chemical Society (ACS)

Abstract：Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous

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