Targeting the SP/KLF Transcriptional Regulatory Network Synergizes with HDAC Inhibition to Impede Progression of H3K27M Diffuse Intrinsic Pontine Glioma

已完结 20 由 Dorothy 发布于 2025/9/14 19:54:48

DOI:10.1158/0008-5472.can-24-2227
作者：Yu Kong, Fan Wang, Renwei Jing, Qian Zhao, Xuejiao Lv, Yingying Zhao, Ye Yuan, Xianyou Xia, Yu Sun, Yujie Tong, Han Yan, Qian Li, Ting Li, Lei Cao, Deng Liu, Dawei Huo, Shao-Kai Sun, Francisco Morís,
文献类型：期刊论文
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American Association for Cancer Research (AACR)

Abstract：Diffuse intrinsic pontine gliomas (DIPGs) are lethal pediatric brain tumors that frequently harbor H3K27M mutations and lack effective treatments. Here, our epigenomic analyses uncovered an

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