Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide

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DOI:10.1126/science.aed8713
作者：Artis Klapars,?Anna Fryszkowska,?Stephanie Galanie,?Omer Ad,?Ellen Y. Aguilera,?Nnamdi Akporji,?Chihui An,?Stephanus Axnanda,?Tewoderos M. Ayele,?Richard S. Ayikpoe,?Rodell C. Barrientos,?Matthew R. B
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Historically, many compelling therapeutic targets have been accessible only by injectable biologic drugs. Macrocyclic peptides, such as the proprotein convertase subtilisin/kexin type 9 inhi

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