Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

已完结 10 由 5 发布于 2025/9/25 8:26:41

DOI:10.1038/s41589-025-01929-w
作者：Stephen A. Rettie, David Juergens, Victor Adebomi, Yensi Flores Bueso, Qinqin Zhao, Alexandria N. Leveille, Andi Liu, Asim K. Bera, Joana A. Wilms, Alina üffing, Alex Kang, Evans Brackenbrough, Mila
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Nature

Abstract：Developing macrocyclic binders to therapeutic proteins typically relies on large-scale screening methods that are resource intensive and provide little control over binding mode. Despite pro

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