BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction

已完结 10 由 SDRD 发布于 2025/8/19 14:24:44

DOI:10.1126/science.adq2004
文献类型：期刊论文
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文献链接：https://doi.org/10.1126/science.adq2004

American Association for the Advancement of Science (AAAS)

Abstract：BBO-10203 is an orally available drug that covalently and specifically binds to the rat sarcoma (RAS)–binding domain of phosphoinositide 3-kinase α (PI3Kα), preventing its activation by HRAS

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