Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency.

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DOI:10.1182/blood.2024026131
作者：Jianli Tao, Luca Alessandri, Alessandro Gasparetto, Lijuan Zhao, Xuefei Zhang, Frederick W Alt, Roberto Chiarle
文献类型：期刊论文
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American Society of Hematology (ASH)

Abstract：Abstract: The enhancer of zeste homolog 2 (EZH2) histone methyltransferase inhibitors tazemetostat and valemetostat recently have received approval for clinical use in follicular lymphoma an

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