Abstract ND01: AMG 410: An H/NRAS-sparing pan-KRAS inhibitor with dual GTP(on)/GDP(off)-state activity for the treatment of diverse KRAS-mutant tumors

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DOI:10.1158/1538-7445.am2025-nd01
作者：Brian A. Lanman, Ryan P. Wurz, Rati Verma, Tao Osgood, Kevin Gaida, Deanna Mohn, Ying-Chu Chen, Gilbert Diaz, Anne Y. Saiki, Paul E. Hughes, Christopher Mohr, Amit Vaish, Yanyan Tudor, Upendra P. Daha
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American Association for Cancer Research (AACR)

Abstract：KRAS is one of the most frequently mutated oncogenes in human cancer (present in ∼25% of cancers). Recent approvals of covalent KRAS G12C inhibitors (KRAS G12Ci) have demonstrated that this

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