Design and synthesis of 7-membered lactam fused hydroxypyridinones as potent metal binding pharmacophores (MBPs) for inhibiting influenza virus PAN endonuclease

已完结 20 由 Zhang Yan 发布于 2025/8/20 18:53:44

DOI:10.1016/j.ejmech.2024.116639
作者：Lei Zhang , Di Ke , Yuting Li , Hui Zhang , Xi Zhang , Sihan Wang , Shaokai Ni , Bo Peng , Huixuan Zeng , Tingjun Hou , Yushen Du , Peichen Pan ,
文献类型：期刊论文
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Elsevier

Abstract：Since influenza virus RNA polymerase subunit PAN is a dinuclear Mn2+ dependent endonuclease, metal-binding pharmacophores (MBPs) with Mn2+ coordination has been elucidated as a promising str

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