Single cell transcriptional landscape of liver transplant rejection reveals tissue persistence of clonally expanded, treatment-resistant T cells.

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DOI:10.1016/j.ajt.2025.08.004
作者：Anna L Peters,Erica A K DePasquale,Gousia Begum,Krishna M Roskin,Michael Kotliar,Artem Barski,Nathan Salomonis,Tiffany Shi,Sarangarajan Ranganathan,E Steve Woodle,David A Hildeman
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Abstract：T cell mediated rejection (TCMR) affects ∼50% of pediatric liver transplant recipients within 5 years, and late TCMR is associated with graft failure due to ineffective treatment. Although C

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