Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

已完结 20 由鱼发布于 2025/8/28 10:52:23

DOI:10.1158/2159-8290.cd-24-1738
作者：Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon, Elias Rodriguez-Fos, Konstantin Helmsauer, Hui Hui, Susmita Mandal, Karin Purshouse, Lara Fankh?nel, Bartolomeo Bosco, Bastiaan Spanjaard, Hannah
文献类型：期刊论文
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American Association for Cancer Research (AACR)

Abstract：Extrachromosomal DNA (ecDNA) amplification enhances intercellular oncogene dosage variability and accelerates tumor evolution by violating foundational principles of genetic inheritance thro

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