Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZ

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DOI:10.1021/acs.oprd.2c00325
作者：Guisheng Li, Zhulin Tan, Yibo Xu, Kanwar P. S. Sidhu, Bo Qu, Melissa A. Herbage, Magnus C. Eriksson, Xingzhong Zeng, Carl A. Busacca, Jean-Nicolas Desrosie
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The development of large-scale syntheses of two beta-site amyloid precursor protein cleaving enzyme (BACE) inhibitors is described. New methodologies were discovered to overcome safety and s

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