Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations

已完结 20 由 madeinheaven 发布于 2025/9/4 0:08:30

DOI:10.1158/2159-8290.cd-24-0614
作者：Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, Radha Mukherjee, Ilinca Aricescu, Vla
文献类型：期刊论文
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文献链接：https://doi.org/10.1158/2159-8290.cd-24-0614

American Association for Cancer Research (AACR)

Abstract：RAS genes are frequently mutated in cancer, often at codons 12 and 61. With the recent introduction of RAS inhibitors, we can now directly investigate the effects of specific RAS mutations i

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