Drug–drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers

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DOI:10.1016/j.bmc.2024.117674
作者：Hikaru Fujita ,?Sachiko Arai ,?Hiroshi Arakawa ,?Kana Hamamoto ,?Toshiyuki Kato ,?Tsubasa Arai ,?Nanaka Nitta ,?Kazuki Hotta ,?Natsuko Hosokawa ,?Takako Ohbayashi ,?Chiaki Takahashi ,?Yasuhide Inokuma
文献类型：期刊论文
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Elsevier

Abstract：Controlling RAS mutant cancer progression remains a significant challenge in developing anticancer drugs. Whereas Ras G12C-covalent binders have received clinical approval, the emergence of

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