Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases

已完结 10 由哈哈哈哈发布于 2025/9/3 15:06:36

DOI:10.1021/acs.jmedchem.3c02422
作者：Robert A. Craig II,?Javier De Vicente,?Anthony A. Estrada,?Jianwen A. Feng,?Katrina W. Lexa,?Mark J. Canet,?William E. Dowdle,?Rebecca I. Erickson,?Brittany N. Flores,?Patrick C. G. Haddick,?Lesley A.
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Eukaryotic translation initiation factor 2B (eIF2B) is a key component of the integrated stress response (ISR), which regulates protein synthesis and stress granule formation in response to

应助信息

求助已完结，文件已删除 如有需求请重新发布求助一键发布

感谢使用Book学术
本站所有文献仅供个人学习和参考，请勿将文件进行传播。共同遵守网站规定和相关知识产权规定。

上一个求助:其它数据库Naturally Fractured Carbonate Reservoir Characterization: A Case Study of a Mature High-Pour Point Oil Field in Hungary 下一个求助:其它数据库More useful maleimide compounds for the conjugation of Fab' to horseradish peroxidase through thiol groups in the hinge.