Development of a Manufacturing Process for a Key (S)-5-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)-1H-indole Intermediate for Orforglipron. Part II. Development of a CSTR Process for Evans Auxiliary-Assisted Asymmetric 1,4-Addition

已完结 10 由 Jason 发布于 2025/9/8 10:16:07

DOI:10.1021/acs.oprd.5c00184
作者：Qiang Yang*, Derek R. Starkey, Radhe K. Vaid, Xavier Ortiz-Medina, Charles B. Held, Mark D. Argentine, Derek Berglund, Molly Hess, Alison Campbell Brewer, 
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：A scalable 8-step route incorporating Evans auxiliary-assisted asymmetric 1,4-addition was developed for a key (S)-5-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-1H-indole intermediate of orforgli

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