Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity

已完结 10 由饼干发布于 2025/4/18 15:31:58

DOI:10.1021/acs.jmedchem.4c03108
作者：Oscar Mammoliti, Rodrigo Carbajo, Laura Perez-Benito, Xiaodi Yu, Marion L. C. Prieri, Leonardo Bontempi, Sofie Embrechts, Ine Paesmans, Michela Bassi, Anindya Bhattacharya, Santiago Ca?ellas, Saskia D
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：NLRP3 is a danger sensor protein responsible for inflammasome activation. This leads to pro-inflammatory cytokines release, like IL-1β, and pyroptosis, a regulated cell death. Mounting evide

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