Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754

已完结 10 由大欣发布于 2025/4/22 14:45:11

DOI:10.1021/acs.oprd.4c00539
作者：Thomas J. Beauchamp, Kevin P. Cole, Howard B. Broughton, David A. Coates, Graham Robert Cumming, Jose Eugenio de Diego, Kwame Frimpong, Julio Gutierrez, William Holloway, Ian Hotham, Spencer Jones, Ta
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Abstract：The chemical development and production of sufficient amounts of IL-17A inhibitor LY3509754 to enable preclinical toxicology studies is described. LY3509754 is a complex small molecule that

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