Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer

已完结 10 由小小发布于 2025/4/22 9:19:44

DOI:10.1021/acs.jmedchem.2c01058
作者：Xin-Chen Jiang,?Fang-Hai Tu,?Li-Yuan Wei,?Bo-Zheng Wang,?Hao Yuan,?Jing-Mei Yuan,?Yong Rao,?Shi-Liang Huang,?Qing-Jiang Li,?Tian-Miao Ou,?Hong-Gen Wang,?Jia-Heng Tan,?Shuo-Bin Chen* and Zhi-Shu Huang*
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The development of triple-negative breast cancer (TNBC) is highly associated with G-quadruplex (G4); thus, targeting G4 is a potential strategy for TNBC therapy. Because concomitant histone

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