Overcoming extracellular vesicle-mediated fratricide improves CAR T cell treatment against solid tumors.

已完结 10 由 1 发布于 2025/4/21 18:23:18

DOI:10.1038/s43018-025-00949-8
作者：Wenqun Zhong, Zhiyuan Qin, Ziyan Yu, Jingbo Yang, Dongdong Yan, Nils Wolfgang Engel, Neil C. Sheppard, Yi Fan, Ravi Radhakrishnan, Xiaowei Xu, Leyuan Ma, Serge Y. Fuchs, Carl H. June, Wei Guo
文献类型：期刊论文
补充材料：只需要正文

Nature

Abstract：The efficacy of chimeric antigen receptor (CAR) T cells against solid tumors is limited. The molecular mechanisms underlying CAR T cell resistance are yet to be elucidated and new strategies

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