PRT3789 is a First-in-Human SMARCA2-Selective Degrader that Induces Synthetic Lethality in SMARCA4-Mutated Cancers

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DOI:10.1158/0008-5472.can-25-1141
作者：Michael Hulse, Min Wang, Chaoyi Xu, Jack Carter, Anjana Agarwal, Liang Lu, Philip Pitis, Neha Bhagwat, Joseph Rager, Justin Kurian, Corey Basch, Monisha Sivakumar, Jessica Burtell, Arpita Mondal, Alex
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American Association for Cancer Research (AACR)

Abstract：SMARCA2 and SMARCA4 are the core catalytic subunits of the SWI/SNF chromatin remodeling complex. Approximately 10% of non-small cell lung cancer (NSCLC) patients harbor SMARCA4 mutations, re

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