Discovery of a novel water-soluble, rapid-release triptolide prodrug with improved drug-like properties and high efficacy in human acute myeloid leukemia

已完结 10 由小小发布于 2025/4/23 10:45:21

DOI:10.1016/j.ejmech.2022.114694
作者：Di Kang ,?Xiang Pan ,?Yi Song ,?Yan Liu ,?Dan Wang ,?Xuejun Zhu ,?Junwei Wang ,?Lihong Hu
文献类型：期刊论文
补充材料：只需要正文

Elsevier

Abstract：In this work, a series of water-soluble triptolide prodrugs were synthesized, and their triptolide release rate, pharmacokinetic characteristics and anti-tumor effect were measured. We found

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