Evaluation of Double Self-Immolative Linker-Based Antibody–Drug Conjugate FDA022-BB05 with Enhanced Therapeutic Potential

已完结 10 由少年发布于 2025/4/28 16:03:27

DOI:10.1021/acs.jmedchem.4c02243
作者：Yifan Zhang, Lei Wang, Xuemei Cao, Ruiwen Song, Sicheng Yin, Zhiyang Cheng, Weinan Li, Keyu Shen, Teng Zhao, Jun Xu, Shuangxi Liu, Qian Xie, Yinghan Wu, Bei Gao, Qingsong Guo, Jingsong Wu, Xuefei Qiu,
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Typical antibody–drug conjugates (ADCs) with valine–alanine linkage, often conjugated with the amino group in payloads, face challenges when interacting with hydroxyl group-containing payloa

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