Ultrasensitive detection of clinical pathogens through a target-amplification-free collateral-cleavage-enhancing CRISPR-CasΦ tool

已完结 10 由七发布于 2025/4/27 21:38:49

DOI:10.1038/s41467-025-59219-x
作者：Huiyou Chen, Fengge Song, Buhua Wang, Hui Huang, Yanchi Luo, Xiaosheng Han, Hewen He, Shaolu Lin, Liudang Wan, Zhengliang Huang, Zhaoyong Fu, Rodrigo Ledesma-Amaro, Dapeng Yin, Haimei Mao, Linwen He,
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1038/s41467-025-59219-x

Nature

Abstract：Clinical pathogen diagnostics detect targets by qPCR (but with low sensitivity) or blood culturing (but time-consuming). Here we leverage a dual-stem-loop DNA amplifier to enhance non-specif

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