Engineering TCR-controlled fuzzy logic into CAR T?cells enhances therapeutic specificity

已完结 10 由 Allen 发布于 2025/4/25 17:54:30

DOI:10.1016/j.cell.2025.03.017
作者：Taisuke Kondo, Fran?ois X.P. Bourassa, Sooraj Achar, Justyn DuSold, Pablo F. Céspedes, Makoto Ando, Alka Dwivedi, Josquin Moraly, Christopher Chien, Saliha Majdoul, Adam L. Kenet, Madison Wahlsten, A
文献类型：期刊论文
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Elsevier

Abstract：Chimeric antigen receptor (CAR) T cell immunotherapy represents a breakthrough in the treatment of hematological malignancies, but poor specificity has limited its applicability to solid tum

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