Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody-Drug Conjugate Payloads.

已完结 10 由 11 发布于 2025/5/3 11:08:06

DOI:10.1021/acs.jmedchem.4c01384
作者：Akash M Patel, Aarron Willingham, Alan C Cheng, Daniela Tomazela, Eddie Bowman, Esther Kofman, Fan Zhang, Jianming Bao, Jillian R Sanzone, Jonathan W Choy,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Toll-like receptors 7 and 8 are involved in modulating the adaptive and innate immune responses, and their activation has shown promise as a therapeutic strategy in the field of immuno-oncol

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