Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling

已完结 10 由 zeng 发布于 2025/5/8 9:23:16

DOI:10.1126/science.adt0548
作者：Yuanheng Yang,?Cong Hao,?Tingying Jiao,?Zidan Yang,?Hui Li,?Yuqing Zhang,?Weiya Zhang,?Michael Doherty,?Chuying Sun,?Tuo Yang,?Jiatian Li,?Jing Wu,?Mengjiao Zhang,?Yilun Wang,?Dongxing Xie,?Tingjian W
文献类型：期刊论文
补充材料：只需要正文

American Association for the Advancement of Science (AAAS)

Abstract：Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid

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